Literature summary for 1.3.8.1 extracted from

Ma, Z.; Qin, X.; Zhong, X.; Liao, Y.; Su, Y.; Liu, X.; Liu, P.; Lu, J.; Zhou, S.
Flavine adenine dinucleotide inhibits pathological cardiac hypertrophy and fibrosis through activating short chain acyl-CoA dehydrogenase (2020), Biochem. Pharmacol., 178, 114100 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
FAD	FAD can promote fatty acid beta--oxidation by activating short-chain acyl-CoA dehydrogenase (SCAD) expression and enzyme activity, and this way inhibit pathological myocardial hypertrophy and fibrosis in vitro and in vivo. Molecular dynamics simulations also demonstrate that FAD may play an important structural role on the SCAD dimer stability and maintenance of substrate catalytic pocket to increase the enzyme activity of SCAD	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P15651	-	-
Rattus norvegicus Sprague-Dawley	P15651	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac muscle fiber	-	Rattus norvegicus	-
heart	left ventricle	Rattus norvegicus	-

Subunits

Subunits	Comment	Organism
More	FAD may play an important structural role on the SCAD dimer stability and maintenance of substrate catalytic pocket	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
SCAD	-	Rattus norvegicus
short chain acyl-CoA dehydrogenase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	FAD activates SCAD expression and enzyme activity, promoting fatty acid beta oxidation	up

General Information

General Information	Comment	Organism
additional information	FAD inhibits PE-induced cardiomyocyte hypertrophy via activating the enzyme, phenotype, overview	Rattus norvegicus
physiological function	short-chain acyl-CoA dehydrogenase (SCAD) is the rate-limiting enzyme in fatty acid beta-oxidation. It has a negative regulatory effect on pathological cardiac hypertrophy and fibrosis	Rattus norvegicus

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Release 2023.1 (January 2023)